Table 1b.
Mean (±SD) of each measure by region for each group: ℓ2 regularized QSM results using phase-guided ROIs and FDRI-guided ROIs
| Region | ℓ2-regularized QSM (ppm), phase-guided ROIs | ℓ2-regularized QSM (ppm), FDRI-guided ROIs | ||||
|---|---|---|---|---|---|---|
| Young (N=11) | Elderly (N=12) | t(elderly>young) | Young (N=11) | Elderly (N=12) | t(elderly>young) | |
| Frontal WM | 0.0240 (0.0146) | 0.0191 (0.0143) |
t= −0.8163a p=0.2118 |
0.0228 (0.0156) | 0.0187 (0.0124) |
t= −0.7029a p=0.2449 |
| Thalamus | 0.0388 (0.0214) | 0.0155 (0.0194) |
t= −2.738a p=0.0061 |
0.0344 (0.0199) | 0.0139 (0.0211) |
t= −2.3931a p=0.0131 |
| Caudate | 0.0814 (0.0164) | 0.0897 (0.0195) |
t=1.1032 p=0.1412 |
0.0653 (0.0211) | 0.0888 (0.0276) |
t=2.2814 p=0.0166 |
| Putamen | 0.0677 (0.0168) | 0.1101 (0.0248) |
t=4.7501 p=0.0001 |
0.0568 (0.0176) | 0.0976 (0.0264) |
t=4.3091 p=0.0002 |
| Globus Pallidus | 0.1069 (0.0188) | 0.1341 (0.0233) |
t=3.0833 p=0.0028 |
0.1221 (0.0153) | 0.1740 (0.0298) |
t=5.1724 p=0.0001 |
| Substantia Nigra | 0.0656 (0.0280) | 0.0939 (0.0246) |
t=2.5812 p=0.0087 |
0.0832 (0.0354) | 0.1210 (0.0227) |
t=3.0743 p=0.0029 |
| Red Nucleus | 0.0740 (0.0333) | 0.1184 (0.0331) |
t=3.2024 p=0.0021 |
0.0738 (0.0339) | 0.1141 (0.0379) |
t=2.6751 p=0.0071 |
| Dentate Nucleus | 0.0570 (0.0137) | 0.0509 (0.0178) |
t= −0.9161a p=0.1850 |
0.04314 (0.0146) | 0.0400 (0.0147) |
t= −0.5076a p=0.3085 |
p-values are 2-tailed. Numbers in bold indicate significant differences, family-wise Bonferroni corrected based on one-tailed directional hypotheses, requiring p ≤.0.0125 for 8 comparisons.
a
Negative t values indicate a group difference with the elderly having less iron than the young.