TABLE 1.
Survey of genes induced by heat shock in the cochlea of wild-type and Hsf1−/− mice
| Common name | Gene symbol | GeneBank ID | Fold changea | |
|---|---|---|---|---|
| Hsf1+/+ | Hsf1−/− | |||
| Hsp70.1 | Hspa1b | NM_010478 | 975 | 1.0 |
| Hsp70.3 | Hspa1a | NM_010479 | 1,300 | 1.0 |
| Hsp25 | Hspb1 | NM_013560 | 28 | 1.00 |
| Hsp47 | Serpinh1 | NM_009825 | 14.0 | ND |
| Hsp110 | Hsp110 | NM_013559 | 8.3 | ND |
| Hsp86/Hsp90α | Hspca | NM_010480 | 5.3 | 1.0 |
| Hsp84/Hsp90β | Hspcb | NM_008302 | 2.9 | 1.0 |
| Hsp32 | Hmox1 | NM_010442 | 1.6 | ND |
| Amyloid beta precursor | App | NM_007471 | 1.0b | 1.0 |
| Clusterin | Clu | NM_013492 | 1.0 | 1.0 |
| Superoxide dismutase | Sod1 | NM_011434 | 1.0 | ND |
| Hypoxia inducible factor 1α | Hif1a | NM_176958 | 1.0 | ND |
ND not determined
aFold change: ratio of mRNA in RNA from induced/RNA from control (uninduced) cochleae
bA ratio of 1.0 indicates no significant change between the control and the heat-shocked mice