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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: J Neurochem. 2011 Nov 28;120(Suppl 1):125–139. doi: 10.1111/j.1471-4159.2011.07478.x

Figure 2. Temporal accumulation of endogenous Aβ dimers in brain tissue of Tg2576 mice.

Figure 2

(A) Western blots showing the relative levels of Aβ dimers detected following immunoprecipitation using formic acid extracts. Dimeric Aβ levels increase in parallel to plaque accumulation in Tg2576, suggesting that dimers are closely related to deposited amyloid. (B) Densitometry analysis of formic acid-soluble Aβ monomers and dimers in Tg2576. Empty circles represent monomeric Aβ while filled black circles correspond to Aβ dimers (n = 3/group). (C) Relative ratio between Aβ monomers and Aβ dimers in Tg2576.*, non-specific band due to the immunoprecipitation.