Table 1.
Metabolites Increased in media with End-Stage OA Versus Early/No OA
| Metabolite | Pathway | Mean Fold Change | p-Value |
|---|---|---|---|
| p<0.05 | |||
| Pro-hydroxyproline | Collagen degradation | 1.60 | 0.001 |
| Acetylcarnitine | Lipid, carnitine, TCA cycle | 1.42 | 0.002 |
| Myo-inositol | Lipid, inositol | 1.30 | <0.001 |
| N-acetylornithine | Urea cycle, AA | 1.24 | 0.029 |
| Succinate | TCA cycle | 1.24 | 0.015 |
| Glutamine | AA, TCA cycle | 1.19 | <0.001 |
| Urea | Urea cycle, AA | 1.06 | 0.03 |
| 0.05<p<0.1 | |||
| Beta-alanine | AA, pyrimidine degradation | 1.50 | 0.055 |
| Uracil | Pyrimidine | 1.48 | 0.087 |
| Arabitol | Carbohydrate | 1.30 | 0.095 |
| Catechol sulfate | Benzoate | 1.17 | 0.015 |
| P-cresol sulfate | AA | 1.12 | 0.057 |
AA = Amino Acid; BCAA = Branched Chain AA; TCA = Tricarboxylic Acid