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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2011 Oct 18;258(1):51–60. doi: 10.1016/j.taap.2011.10.007

Fig. 9.

Fig. 9

Western blot analysis show decreased expression of Chk1 and Chk2. (A) Digitoxin and D6-MA down-regulated Chk1 and Chk2 in a dose dependent manner. (B) D6-MA is more potent than digitoxin in inhibiting Chk1 expression (F=10.17, p<0.001). Quantification of Chk1 blots shows decreased expression following treatment (*p<0.05 compared 0 nM, †p<0.05 compared to respective digitoxin treatment). (C) D6-MA is more potent than digitoxin in inhibiting Chk2 expression (F=7.982, p<0.001). Quantification of Chk2 blots shows decreased expression following treatment (*p<0.05 compared 0 nM, †p<0.05 compared to respective digitoxin treatment).