Fig. 1.

The neuroprotective effects of glycyrrhizin in the postischemic brain. (A, B) Stronger Neo-Minophagen C (SNMC, 1 ml/kg) was administered intravenously at 30 min before or 30 min, 3 h, or 6 h after middle cerebral artery occlusion (MCAO) (60 min). (C, D) SNMC (1 or 2.5 ml/kg) or glycyrrhizin (2 or 5 mg/kg) was administered intravenously at 3 h after MCAO (60 min). (A, C) Representative images of infarctions in coronal brain sections are presented. (B, D) Mean infarction volumes were assessed at 2 days post-MCAO by 2,3,5-triphenyl tetrazolium chlorid (TTC) staining, and are presented as means±SEM (n=4-6). ^*P<0.05, ^†P<0.01.