Figure 4.

Human detrusor ICCs. A, human detrusor labeled with anti-SM myosin (SMM). B, at mucosa-detrusor interface SMCs were arranged in loose network, which was organized into distinct bundles in detrusor muscularis. C to E, representative human detrusor co-labeled with anti-SM myosin and anti-KIT (green areas). Elongated, branched KIT positive ICC track SM bundles and occupy spaces between bundles with obvious spiky morphology. E, nuclei counterstained with 4,6-diamidino-2-phenylindole (blue areas). F, detrusor ICCs (green areas) associated with vAChT nerves (red areas).