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A to E, typical human bladder ICC ultrastructural characteristics include mitochondria (m), Golgi (G), vesicles (v), rER and branched projections (asterisks). Abundant collagen (c) was present in interstitial spaces. In contrast to SMCs, ICCs did not contain thick filaments, dense bands or dense bodies and had incomplete basal lamina. B, close association between 2 ICCs. E, higher magnification of D.
