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. 2009 Jul;182(1):330–336. doi: 10.1016/j.juro.2009.02.108

Figure 1.

Figure 1

XE991 effect on ICC outward currents. A, ICCs were stepped from −60 to 40 mV to evoke outward currents. K+ pipette solution contained 5 mM EGTA and 3 mM ATP to eliminate BK and KATP currents. XE991 application dose dependently decreased outward current. ms, milliseconds. B, there was significant decrease by XE991 in 11 cells. Asterisk indicates p <0.05. C, current family elicited by stepping from −60 to 40 mV in 10 mV increments. Currents were decreased by 10 μM XE991. D, Current-voltage plot demonstrates relationship between mean current and test potentials in absence and presence of XE991. E, KCNQ current was obtained by subtracting XE991 insensitive current from control current, activated positive to −60 mV. It was outwardly rectifying.