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KCNQ opener effect on ICC outward current. A, current family evoked by stepping from −60 to 40 mV in 10 mV increments. Flupirtine application increased outward current amplitude. ms, milliseconds. B, control currents in different cell and MFA effect on outward currents. C, flupirtine effect in 8 cells. D, summary data on MFA effect in 5 cells.
