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. 2009 Jul;182(1):330–336. doi: 10.1016/j.juro.2009.02.108

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© 2009 Elsevier Inc.

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KCNQ pharmacological agents and resting membrane potential. A, ICCs were current clamped to record resting membrane potential. XE991 application depolarized cell. s, seconds. B, in previously quiescent cell XE991 induced firing of spontaneous transient depolarizations, followed by sustained depolarization. C, chromanol 293B application also depolarized cell. D, depolarization by chromanol induced spontaneous transient depolarization firing. E, flupirtine application increased resting membrane potential. F, hyperpolarization by flupirtine inhibited spontaneous electrical activity in active cell. G, effect of KCNQ drugs on membrane potential. Asterisk indicates p <0.05.