Skip to main content
. Author manuscript; available in PMC: 2012 Nov 9.
Published in final edited form as: Structure. 2011 Nov 9;19(11):1582–1590. doi: 10.1016/j.str.2011.10.003

Figure 1.

Figure 1

The sequence of steps constituting codimensional PCA. The analysis requires a set of 2D cryo-EM projection images that are aligned within the common framework of reference yielding an “average” 3D structure of the molecule. As a result of eigenanalysis of resampled structures and calculation of factorial coordinates of 2D projection images, and clustering separation of the projection data set into subsets, the procedure eventually provides structures of putative conformers. See also Figure S1.