Table 1.
Differentially expressed proteins identified by MALDI-TOF PMF. Results of the ANOVA analysis are indicated by arrows in the far right 3 columns representing up- or down-regulation of protein abundance when compared to the young (4-month-old) control group.
| Swiss Prot ID | SSP# | Annotation | pI | Mass | 4→12 | 4→24 | 4→34 |
|---|---|---|---|---|---|---|---|
| Q9Z1N4 | 3401 | 3(2),5-bisphosphate nucleotidase | 5.6 | 33.5 | - | ↑ | ↑ |
| P07953 | 2112 | 6-Phosphofructo-2-KinaseFRUCTOSE-2,6-Bisphosphatase | 5.7 | 22.34 | ↓ | ↓ | ↓ |
| P38918 | 5209 | Aflatoxin Aldehyde Reductase | 6.6 | 37.08 | - | ↑ | ↑ |
| Q5M890 | 1211 | Apolipoprotein N | 5.3 | 28.5 | - | ↑ | ↑ |
| Q80UA1 | 1111 | Beta-1 adducin | 4.9 | 20.9 | - | ↑ | ↑ |
| P02564 | 3620 | Cardiac myosin heavy chain 5 (fragment) | 5.5 | 47.89 | ↓ | ↓ | ↓ |
| Q7TP19 | 5208 | Cb1–812 | 6.8 | 30.53 | ↓ | ↓ | ↓ |
| Q68FW9 | 3608 | COP9 subunit 2 | 5.4 | 51.86 | ↑ | - | ↑ |
| Q6AY36 | 6716 | Coronin, actin binding protein 2A | 7 | 61.59 | - | ↑ | ↑ |
| P09605 | 7507 | Creatine kinase, sarcomeric mitochondrial precursor | 9.2 | 48.87 | - | ↓ | ↓ |
| P48675 | 1617 | Desmin | 5.2 | 53.46 | ↑ | - | ↑ |
| O95173 | 3303 | Dimethylglycine dehydrogenase-like protein | 5.9 | 30.09 | ↑ | ↑ | ↑ |
| P04764 | 4611 | Enolase 1 | 6.7 | 53.3 | - | ↑ | ↑ |
| Q9Z1E1 | 4608 | Flotillin-1 | 6.7 | 47.77 | - | ↑ | - |
| P54311 | 2406 | G protein beta 1 subunit | 5.5 | 38.59 | ↑ | ↑ | - |
| P18645 | 6419 | Galactose-4-epimerase, UDP | 7.9 | 38.55 | ↑ | - | - |
| P04905 | 4216 | Glutathione S-transferase Y-b subunit | 7.9 | 22.04 | - | ↑ | - |
| P26772 | 8013 | Heat Shock Protein 10 | 8.9 | 10.88 | ↓ | - | ↓ |
| P42930 | 2201 | Heat Shock Protein 27 | 6.1 | 22.86 | - | ↑ | ↑ |
| Q641X3 | 5706 | Hexosaminidase A | 6.9 | 61.09 | - | ↑ | ↑ |
| Q9UL88 | 8025 | Immunoglobulin heavy chain variable region | 8.9 | 11.11 | - | - | ↑ |
| Q6IE13 | 4207 | Kallikrein 1 precursor | 6.3 | 26.13 | - | ↑ | ↑ |
| Q64361 | 4212 | Latexin | 5.8 | 26.36 | - | ↑ | ↑ |
| P11884 | 4606 | Mitochondrial aldehyde dehydrogenase precursor | 6.4 | 56.07 | - | - | ↑ |
| RGD:62029 | 3408 | Myosin H (fragment) | 5.4 | 49.48 | ↓ | ↓ | ↓ |
| Q6LEH0 | 1112 | Myosin heavy chain (fragment) | 5.3 | 20.16 | - | ↑ | ↑ |
| P02563 | 2506 | Myosin heavy chain (fragment) | 5.2 | 44.9 | - | ↑ | ↑ |
| P02601 | 116 | Myosin Light Chain 3-f | 4.6 | 16.72 | - | - | ↑ |
| P08733 | 1003 | Myosin regulatory light chain 2 | 4.2 | 12.57 | - | ↑ | ↑ |
| Q63862 | 2825 | Myosin-11 (fragment) | 5.1 | 71.76 | ↓ | ↓ | ↓ |
| P04462 | 4217 | Myosin-8 (fragment) | 6.4 | 29.83 | ↑ | ↑ | ↑ |
| P02625 | 1006 | Parvalbumin | 5 | 12.58 | - | ↑ | ↑ |
| O35244 | 3203 | Peroxiredoxin 6 | 5.6 | 25.61 | - | - | ↑ |
| P31044 | 2102 | Phosphatidylethanolamine binding protein | 5.5 | 20.9 | - | ↑ | ↑ |
| Q63321 | 5814 | Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 | 6.3 | 84.16 | - | - | ↑ |
| Q6AYD3 | 4417 | Proliferation-associated 2G4 | 6.4 | 45.75 | ↑ | ↑ | ↑ |
| P09216 | 6803 | Protein kinase C epsilon | 6.6 | 84.93 | - | - | ↑ |
| O35331 | 4421 | Pyridoxal kinase | 6.3 | 35.83 | - | ↑ | ↑ |
| P49432 | 2403 | Pyruvate dehydrogenase (lipoamide) beta | 6.2 | 40.11 | - | ↑ | ↑ |
| P62824 | 1209 | RAB3C | 5.2 | 26.11 | - | ↑ | ↑ |
| Q6PAG9 | 6110 | RBL-NDP kinase 18kDa subunit | 6.9 | 17.88 | - | ↑ | ↑ |
| P60711 | 3609 | Similar to cytoplasmic beta-actin | 5.3 | 43.04 | ↑ | ↑ | - |
| Q6AXM9 | 6308 | Similar to RIKEN cDNA C430008C19 | 6.5 | 23.9 | ↑ | ↑ | ↑ |
| Q5I0J4 | 2002 | Spindle and kinetochore-associated protein 2 | 5.7 | 16.67 | - | ↑ | ↑ |
| Q920L4 | 2003 | TAFIIB | 5.5 | 14.16 | - | - | ↑ |
| P12346 | 5817 | Transferrin | 7 | 78.57 | - | ↑ | ↑ |
| Q5FVG5 | 1305 | Tropomyosin 1 | 4.6 | 33 | - | ↑ | ↑ |
| P62989 | 6010 | Ubiquitin | 6.6 | 8.55 | - | ↑ | ↑ |