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letter
. 2011 Aug 26;1(8):e33. doi: 10.1038/bcj.2011.31

Figure 1.

Figure 1

Mutation of the SUZ12 gene in MPNs. (a) Localization of the SUZ12 gene in chromosomal region 17q11. (b) Representation of the 16 SUZ12 exons. (c) Representation of the 739-amino-acid-long SUZ12 protein with known motifs and domains. Localization of the mutations is indicated below by arrowheads. (d) Nucleotide sequences for HD-0716 PV case. Sequence of the mutated SUZ12 allele demonstrates change at the position indicated by an arrow in the sample taken at diagnosis. (e) The mutation was hardly detectable after 2 years of treatment and is absent from CD3 T-cells and buccal swab samples. The corresponding sequence is shown above the tracks.