Table 1. Mutations and deletions of SUZ12 in patients with myeloproliferative neoplasms.
SUZ12 mutation | SUZ12 loss | ASXL1 mutation | ASXL1 loss | DNMT3A mutation | IDH1/2 mutation | JAK2 mutation | MPL mutation | TET2 mutation | TET2 loss | |
---|---|---|---|---|---|---|---|---|---|---|
Polycythemia vera | 1/33 | 0/7 | 3/33 | 0/7 | 1/33 | 0/33 | 32/33 | 0/33 | 4/33 | 0/7 |
Essential thrombocythemia | 0/51 | 0/19 | 2/51 | 0/19 | 0/51 | 0/51 | 32/51 | 0/51 | 3/51 | 0/19 |
Myelofibrosis | 0/35 | 1/35 | 8/35 | 1/35 | 1/35 | 0/35 | 24/35 | 0/35 | 4/35 | 0/35 |
Other MPN | 0/6 | 0/6 | 2/6 | 0/6 | 0/6 | 0/6 | 1/6 | 0/6 | 2/6 | 0/6 |
Blast phase MPN | 1/14a | 2/13a | 2/14 | 0/13 | 0/14 | 2/14 | 4/14 | 1/14 | 2/14a | 2/13a |
Total MPNs | 2/139a | 3/80a | 17/139 | 1/80 | 2/139 | 2/139 | 93/139 | 1/139 | 15/139a | 2/80a |
Abbreviation: MPN, myeloproliferative neoplasm.
HD-1038 sample in common.