Table 3. Multivariate analysis of prognostic factors and risk stratification by combination of KPS⩽70%, moderate or severe lung disease and eGFR<30.

Comorbidity factors	Definition	n	HR (95% Confidence interval)	P-valuea
KPS	>70%	88	2.17 (1.23–3.82)	0.0077
	⩽70%	39
Lung disease	No/mild	104	2.78 (1.53–5.04)	0.0008
	Moderate/severe	23
eGFRMDRD (ml/min/1.73m2)	⩾30	115	2.93 (1.33–6.46)	0.0075
	<30	12
FCI	Median OS (months)	n	HR (95% Confidence interval)	P-valuea
0	118	74	1.0 (reference)	—
1	53	36	2.5 (1.4–4.5)	0.0033
2 or 3	25	17	6.5 (3.2–13.2)	< 0.0001

Abbreviations: eGFR_MDRD, estimated glomerular filtration rate by MDRD (Modification of Diet in Renal Disease); FCI, Freiburger comorbidity index; HR, hazard ratio; KPS, Karnofsky Performance Status; OS, overall survival.

^aχ²-test.