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. 2011 Jun 24;1(6):e26. doi: 10.1038/bcj.2011.24

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Copyright © 2011 Macmillan Publishers Limited

This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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High level of CXCR4 membrane protein expression is correlated with a low level of miR-146a expression in AMLs. (a) Quantitative real-time (qRT)-PCR analysis of miR-146a expression levels in primary AML samples (from M1 to M5 of FAB classification) compared with normal CD34⁺ HPCs. (b) FACS of CXCR4 membrane protein expression levels in the same AML samples. (c) RT-PCR analysis of CXCR4 mRNA expression in AMLs samples. (d) Negative correlation between CXCR4 levels and miR-146a expression (P⩽0.0001). (e) Direct correlation between CXCR4 mRNA and protein levels (P⩽0.05).