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. 2012 Jan 3;4:2. doi: 10.3410/B4-2

Figure 1. Oncogenic and tumor suppressor control of metabolism.

Figure 1.

Oncogene (yellow) and tumor suppressors (light blue) control metabolism directly (isocitrate dehydrogenase, succinate dehydrogenase/fumarate hydratase, 3-phosphoglycerate dehydrogenase) or indirectly. Mechanisms including phosphorylation, and transcription, and proteolysis are illustrated. Key: broken lines indicate an indirect connection (i.e. non-direct biochemical events); unbroken lines indicate the two proteins interacting.

Abbreviations: FH, fumarate hydratase; GLS1, glutaminase 1; HK2, hexokinase 2; IDH, isocitrate dehydrogenase; LDHA, lactate dehydrogenase A; OXPHOS, oxidative phosphorylation; PDH: pyruvate dehydrogenase; PDK1, pyruvate dehydrogenase kinase, isozyme 1; PFKFB3, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, isoform 3; PGK, phosphoglycerate kinase; PHGDH, 3-phosphoglycerate dehydrogenase; PKM2, pyruvate kinase M2 isoform; PPP, pentose phosphate pathway; SDH, succinate dehydrogenase.