Table 2.
MARV protein sequences recognized by murine H-2d CD8+ T cells. Summary of data is from [102].
| MARV protein | 15-mer peptide sequence | Minimal peptidea | Amino acid position | Adoptive transfer protectionb |
|---|---|---|---|---|
| Glycoprotein | FLISLILIQGTKNLP | ILIQGTKNL | 11–19 | 50 |
| ILIQGTKNLPILEIA | QGTKNLPIL | 14–22 | 20 | |
| TCYNISVTDPSGKSL | VTDPSGKSL | 97–105 | NT | |
| SGKSLLLDPPTNIRD | LLLDPPTNI | 105–113 | 0 | |
| SPPPTPSSTAQHLVY | TPSSTAQHL | 420–428 | 0 | |
| GILLLLSIAVLIALS | LLLSIAVLI | 659–667 | 100 | |
| LSIAVLIALSCICRI | LSIAVLIAL | 661–669 | 20 | |
| LIALSCICRIFTKYI | IALSCICRI | 667–675 | 40 | |
| Nucleoprotein | AINSGIDLGDLLEGG | NSGIDLGDL | 43–51 | 80 |
| KFNTSPVAKYLRDAG | NTSPVAKYL | 73–81 | 20 | |
| EPHYSPLILALKTLE | HYSPLILAL | 108–116 | 10 | |
| VP40 | QHKNPNNGPLLAISG | KNPNNGPLL | 218–226 | 40 |
a9 mer peptide sequence derived from HLA binding predictions.
bPercentage of animals protected from lethal challenge with mouse-adapted Marburg virus after adoptive transfer of CD8 lymphocytes specific for the 9-mer peptide sequences.
NT: not tested.