Table 1.
Descriptive statistics for representative transplant recipients and donor comorbidities and outcomes over time
1996 to 2009 | 1998 | 2002 | 2006 | P for Trend | |
---|---|---|---|---|---|
Total number of recipients | 150,075 | 12,485 | 14,573 | 15,813 | |
Recipient age and demographics | |||||
age between 21 and 30 years | 10.99% | 12.91% | 10.04% | 8.84% | <0.001 |
age between 31 and 50 years | 45.44% | 50.72% | 45.85% | 38.04% | <0.001 |
age between 51 and 60 years | 25.62% | 23.13% | 26.18% | 28.76% | <0.001 |
age greater than 60 years | 17.85% | 13.24% | 17.93% | 24.35% | <0.001 |
male | 59.76% | 59.14% | 59.23% | 61.44% | 0.01 |
Comorbidities | |||||
recipient has diabetes | 26.35% | 25.91% | 27.42% | 27.62% | 0.01 |
recipient was on dialysis | 75.34% | 77.41% | 77.19% | 75.89% | 0.27 |
recipient had heart or vascular disease | 18.87% | 18.47% | 18.29% | 20.49% | <0.001 |
recipient had hypertension | 74.84% | 69.75% | 76.63% | 81.18% | <0.001 |
recipient had prior transplant(s) | 11.71% | 11.43% | 11.54% | 12.08% | 0.22 |
Wait | |||||
average wait time in years (for deceased donor recipients) | 1.98 | 1.63 | 2.08 | 2.12 | <0.001 |
Recipient outcomes | |||||
3-year graft survival | 82.16% | 81.66% | 82.42% | 84.82% | <0.001 |
3-year patient survival | 90.28% | 90.29% | 90.29% | 91.73% | 0.32 |
Outcome variation across center | |||||
standard deviation of unadjusted 3-year graft survival | 16.1% | 7.84% | 8.60% | 7.30% | 0.72 |
standard deviation of unadjusted 3-year patient survival | 17.0% | 5.14% | 6.35% | 5.59% | 0.76 |
Donor characteristics | |||||
deceased donor | 63.8% | 68.7% | 61.6% | 62.6% | <0.001 |
expanded criteria donors | 10.85% | 10.46% | 8.50% | 12.35% | <0.001 |
average total HLA antigen mismatches (A, B, and DR loci) | 3.39 | 3.13 | 3.33 | 3.60 | <0.001 |
average HLA-A antigen mismatches | 1.19 | 1.14 | 1.18 | 1.23 | <0.001 |
average HLA-B antigen mismatches | 1.29 | 1.16 | 1.25 | 1.40 | <0.001 |
average HLA-DR antigen mismatches | 1.14 | 1.08 | 1.13 | 1.19 | <0.001 |
peak panel reactive antibody (PRA) | 12.02 | 11.57 | 11.83 | 12.10 | <0.001 |
donor weight (kg) | 75.89 | 72.89 | 74.87 | 78.34 | <0.001 |
donor age | 38.34 | 36.65 | 37.61 | 39.54 | <0.001 |
cold ischemia time (hours) | 13.93 | 15.20 | 13.37 | 13.23 | <0.001 |
donor history of diabetes | 3.10% | 2.19% | 3.38% | 4.34% | <0.001 |
donor history of hypertension | 18.42% | 19.23% | 18.74% | 18.19% | 0.23 |