Table 3.

List of the most significant and biologically relevant proteins with increased IgG antibodies in IgAN

Sample Number	Gene Symbol	Gene Name	Present in Glomerulusa	Present in Tubulesa	Highly Kidney Specific from Gene Expression Datab	P
1	PRKD1	Serine/threonine-protein kinase D1	X	X	X	0.03
2	MATN2	Matrilin 2	X	X		<0.01
3	DDX17	DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 2	X	X		<0.01
4	UBE2W	Ubiquitin-conjugating enzyme E2W	NA	NA	X	0.05
5	CDKN1B	Cyclin-dependent kinase inhibitor 1B	X	X		0.02
6	SOD2	Superoxide dismutase 2, mitochondrial	X	X		0.05
7	IQCK	IQ motif containing K	X	X	X	0.05
8	BLZF1	Basic leucine zipper nuclear factor 1	X	X		0.02
9	EFNA3	Ephrin A3	X	X		0.01
10	EIF4A2	Eukaryotic translation initiation factor 4A	X	X		0.05
11	FLII	Flightless I homolog	X	X		0.05
12	LIMCH1	LIM and calponin homology domains 1	X	X		0.05
13	MAGEA4	Melanoma antigen family A, 4	X	X		0.05
14	MEF2D	Myocyte enhancer factor 2D	X	X		0.03
15	MLLT6	Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6	X	X		0.02
16	CIAPIN1	Cytokine induced apoptosis inhibitor 1	NA	NA	X	0.05
17	GDI2	GDP dissociation inhibitor 2	NA	NA	X	0.02
18	HSPA8	Heat shock 70-kD protein 8, transcript variant 1		X	X	0.05
19	SERPINA5	Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	NA	NA	X	0.05
20	TGM1	Transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase)		X	X	0.05

All of the autoantibodies for the corresponding proteins were significantly increased in IgA nephropathy (IgAN) compared with healthy controls (P ≤ 0.05). X, yes. NA, not available.

^aNo immunohistochemistry data available.

^bWith a false discovery rate < 5%.