Table 4.
Associated pathways and molecular functions for increased autoantibodies specific to IgA nephropathy
| Molecular Pathway/Function | Associated Antigens | P |
|---|---|---|
| Apoptosis | IGHG1, IGHG3, NEK2, TNS1, EDIL3, CDKN1B, ABCD1, KIFC3, HSPA8, RAB38, SOD2, TOM1, RASA1, AGAP1, CD7, IGHM, CKM, JAK3, SEPT5, BLZF1, and CDKN1B | ≤0.05 |
| Cellular assembly and organization | ABCD1, AGAP1, BLZF1, CD7, CDKN1B, CKM, EDIL3, HSPA8, IGHG1, IGHM, JAK3, KIFC3, NEK2, SEPT5, SOD2, TNS1, RASA1, IGHG3, TOM1, and RAB38 | ≤0.04 |
| Cellular development | CD79A, IGHG1, SART1, RASA1, EFNA3, GNAT2, MED6, CDKN1B, MEF2D, SOX5, CIAPIN1, IGHM, JAK3, NIF3L1, PRKD1, RBPJ, SOD2, TRPV4, and TGM1 | ≤0.05 |
| Immunologic disease | IGHM, IGKC, JAK3, CDKN1B, ALCAM, FCGR3A, and IGHG1 | ≤0.05 |
| Connective tissue disorders | TPRA1 | ≤0.05 |
| Dermatologic conditions | CD79A, IGHG3, IGHM, IGK@, IGL@, PLXNA1, HN1, IGHG1, IGKC, POLH, and TGM1 | ≤0.03 |