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. Author manuscript; available in PMC: 2012 Nov 16.
Published in final edited form as: J Am Chem Soc. 2011 Oct 21;133(45):18447–18451. doi: 10.1021/ja208025e

Figure 1.

Figure 1

The size-expanded architecture of xDNA, in which xA, xC, xT, xG bases are paired opposite natural bases. To encode phenotype in a cell, the 2.4 Å-expanded bases must be read by cellular polymerases accurately and with adequate efficiency.