Table 1.
Changes on the body weight (BW), food and water intake, and weight of white adipose tissue (WAT) in HFD-fed rats receiving 12-weeks treatment with VBRB or fenofibrate.
| Groups | Initial BW (g rat−1) |
BW gain (g rat−1) |
Food intake (g rat−1 per day) | Water intake (mL rat−1 per day) | WAT (mg 100 g−1 BW) | |||
|---|---|---|---|---|---|---|---|---|
| Epididymal | Perirenal | Mesenteric | Inguinal | |||||
| RCD-fed | ||||||||
| Vehicle-treated | 172.5 ± 7.7 | 17.8 ± 6.2b | 19.3 ± 5.9 | 77.2 ± 8.1 | 303.6 ± 15.8b | 172.9 ± 12.7b | 129.8 ± 9.6b | 146.9 ± 11.2b |
| HFD-fed | ||||||||
| Vehicle-treated | 173.4 ± 6.9 | 53.7 ± 7.0 | 20.3 ± 6.7 | 86.3 ± 9.4 | 422.1 ± 21.3 | 263.8 ± 14.2 | 191.7 ± 13.6 | 223.6 ± 14.2 |
| VBRB (g kg−1 per day) | ||||||||
| 0.3 | 172.3 ± 9.3 | 41.4 ± 6.7 | 20.9 ± 6.8 | 82.4 ±10.2 | 368.1 ± 16.1a | 228.6 ± 13.5 | 171.5 ± 13.1 | 194.3 ± 11.8 |
| 0.5 | 173.1 ± 8.4 | 30.7 ± 6.9a | 21.8 ± 6.9 | 80.8 ± 9.7 | 338.5 ± 22.8a | 198.9 ±13.9a | 156.2 ±10.3a | 170.6 ± 11.0a |
| 1.0 | 172.8 ± 6.7 | 23.6 ± 5.3b | 20.3 ± 6.3 | 78.1 ± 7.9 | 308.4 ± 19.2b | 185.3 ± 12.1b | 136.9 ± 8.7b | 151.1 ± 9.2b |
| Fenofibrate (100 mg kg−1 per day) | 171.6 ± 8.1 | 20.4 ± 5.8b | 19.9 ± 7.1 | 76.7 ± 8.9 | 293.9 ± 14.6b | 170.2 ± 11.7b | 125.6 ± 9.2b | 142.2 ± 10.5b |
The vehicle (distilled water) used to solve the tested medications was given at the same volume. Values (mean ± SD) were obtained from each group of 8 animals in each group after 12 weeks of the experimental period. a P < .05 and b P < .01 compared to the values of vehicle-treated HFD-fed rats in each group, respectively.