FIG. 3.

The progression and severity of arthritis was reduced in transgenic mice (A). From 1 week after boosting, the clinical score was determined by visual inspection, as described in the Methods and Materials section. The total number of mice was 5 to 6 in each group (*P<0.05 versus arthritic wild-type mice). The histological examinations of the joints from collagen-induced arthritis mice were performed by hematoxylin and eosin staining. Mice were euthanized on day 42 after the primary immunization. The left hind foot, which received collagen boosting, was excluded. Upper panels (B and C, magnification, ×20 and ×40, respectively) represent the arthritic joints from transgenic mice and lower panels (D and E, magnification, ×20 and ×40, respectively) represent those from wild-type mice. Mean histology score for the degree of inflammation (IFM), synovial hyperplasia (SH), and pannus formation (PF) in transgenic mice and wild-type mice (F). Scale bars: (B and C) 100 μm; (D and E) 200 μm.