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. 2012 Jan;32(1):6–11. doi: 10.1089/jir.2010.0155

FIG. 4.

FIG. 4.

IL-1β and TNFα were repressed in the synovium of transgenic mice but not in peripheral blood. Proinflammatory cytokines levels were tested in peripheral blood serum (A) and (C) and FLS-free culture medium (B) and (D) from the arthritic mice by ELISA. Optical absorbance was measured using an ELISA reader at 540 and 450 nm (*P<0.05 versus arthritic wild-type mice). The expression of cytokines (E) and MMPs (F) was profiled by RT-PCR. FLSs were prepared from arthritic transgenic mice on day 42 after first immunization. Relative expression levels of each cytokine were measured by the Image J software 1.38 (*P<0.05 versus arthritic wild-type mice). MMP, matrix metalloproteinase; IL, interleukin; TNFα, tumor necrosis factor α.