Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2011 Aug 29;5(1):115–124. doi: 10.1242/dmm.008029

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2012. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

PMC Copyright notice

Fig. 1. — Schematic of phosphoinositide generation and recycling. Enzymes involved in recycling of the phosphoinositide head group (inositol) include phospholipase C (PLC), which catalyses the production of inositol trisphosphate (InsP₃) and diacylglycerol (DAG) from phosphatidylinositol diphosphate (PIP₂), which in turn is produced from phosphatidylinositol monophosphate (PIP). Prolyl oligopeptidase (PO) regulates the formation of InsP₃ from higher order inositol phosphates containing 4–6 phosphates (InsP_4–6). InsP₃ is recycled via inositol bisphosphate (InsP₂) and inositol monophosphate (InsP₁) to enable inositol monophosphatase (IMPase) to catalyse the production of inositol. De novo inositol synthesis is catalysed from glucose 6-phosphate (Glu6P) by myo-inositol-3P synthase (INO1). Type 1 phosphatidylinositol 3-kinase (PI3K) is responsible for the phosphorylation of phosphinositides at the 3′ position of the inositol head group, with products including phosphatidylinositol-(3,4,5)-trisphosphate (PIP₃).