Table 1.
Characteristic | Entire Study Cohort(N = 1,087) |
Subgroup With Patient-Reported Outcomes(n = 544) |
||
---|---|---|---|---|
No. | % | No. | % | |
Age at transplantation, years | ||||
Median | 53 | 56 | ||
Range | 21-78 | 21-78 | ||
Follow-up of patients still alive, months | ||||
Median | 37 | 41 | ||
Range | 12-77 | 12-77 | ||
Race* | ||||
White | 857 | 84 | 441 | 86 |
Nonwhite | 167 | 16 | 72 | 14 |
Sex | ||||
Male | 654 | 60 | 326 | 60 |
Female | 433 | 40 | 218 | 40 |
Diagnosis | ||||
Chronic leukemia | 87 | 8 | 37 | 7 |
Acute leukemia | 304 | 28 | 147 | 27 |
Lymphoma | 299 | 28 | 155 | 28 |
Multiple myeloma | 186 | 17 | 98 | 18 |
Myelodysplastic syndrome | 144 | 14 | 74 | 14 |
Other cancer | 15 | 1 | 3 | 1 |
Nonmalignant disease | 52 | 5 | 30 | 6 |
Disease risk | ||||
Early | 236 | 22 | 117 | 22 |
Intermediate | 314 | 29 | 158 | 29 |
Advanced | 485 | 45 | 239 | 44 |
Nonmalignant | 52 | 5 | 30 | 6 |
Transplantation type | ||||
Autologous/syngeneic | 493 | 45 | 259 | 48 |
Related donor | 264 | 24 | 118 | 22 |
Unrelated donor | 330 | 30 | 167 | 31 |
Sex match* | ||||
Female to male | 129 | 12 | 58 | 11 |
Other sex combinations | 461 | 43 | 226 | 42 |
Autologous/syngeneic | 493 | 46 | 259 | 48 |
Graft source | ||||
Peripheral blood | 977 | 90 | 496 | 91 |
Bone marrow | 92 | 8 | 42 | 8 |
Umbilical cord blood | 18 | 2 | 6 | 1 |
Conditioning | ||||
High-dose therapy with total body irradiation† | 236 | 22 | 111 | 20 |
High-dose therapy without total body irradiation† | 688 | 63 | 350 | 64 |
Reduced intensity | 163 | 15 | 83 | 15 |
Graft-versus-host disease (allogeneic patients) | ||||
Acute grade 2 | 364 | 61 | 176 | 62 |
Acute grade 3 | 46 | 8 | 21 | 7 |
NIH chronic treated with systemic treatment‡ | 344 | 60 | 179 | 64 |
Abbreviation: NIH, National Institutes of Health.
Race unknown for 63 patients in overall study cohort and for 31 patients in quality-of-life subgroup; sex match unknown for four patients in overall study cohort and one patient in quality-of-life subgroup.
Antithymocyte globulin included in conditioning regimen for 57 patients in overall study cohort and for 32 patients in quality-of-life subgroup.
Cumulative incidence at 5 years.