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. Author manuscript; available in PMC: 2012 Jan 11.
Published in final edited form as: Tuberculosis (Edinb). 2009 Sep 15;89(5):334–353. doi: 10.1016/j.tube.2009.05.008

Table 10.

Antitubercular Activities of 2,4-Diaminoquinazolines

graphic file with name nihms-146470-t0019.jpg
Cpd.No. R1 Ar R2 TB
IC90
SI
16a H Ph CH2CH2OPh(4-Me) 1.5 9.8
16b Me Ph COPh(4-Cl) 1.6 3.0
16c H Ph CH2Ph 1.7 8.8
16d H 2-Furyl CH2C=CH2(CH3) 6.1 2.5
16e H 2-Furyl CH2CH2OPh(4-Me) 9.6 1.6