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. Author manuscript; available in PMC: 2012 Jan 11.
Published in final edited form as: Tuberculosis (Edinb). 2009 Sep 15;89(5):334–353. doi: 10.1016/j.tube.2009.05.008

Table 3.

Antitubercular Activities of Substituted Benzopyran-2-ones

graphic file with name nihms-146470-t0009.jpg
Cpd.
No.		 R1 R2 R3 R4 R5 R6 R7 TB
IC90 		SI
2a H Ph H H H cC6H11 H 0.18 >83
2b H 3-nitro
phenyl		 H H H i-Pr H 0.45 >33
2c H n-butyl H Cl H Et Me 0.64 >23
2d H n-butyl H Cl H CH2Ph H 0.66 >23
2e H 3-nitro
phenyl		 H H H Me H 0.78 >19
2f CH2CO2Me Me H H Me CH2Ph H 1.03 >15
2g H 4-
methoxy
phenyl		 H H H H 1.7 >9
2h Et Me H H Me Me H 1.8 >8
2i 2-
benzothiazolyl		 H H H H Et H 2.7 >6
2j -(CH2)5- H H H Et H 3.5 >4
2k Cl CH3 OCH2CO2Me H H Me H Inact. -
2l -(CH2)3)- H H H Me Ph * -
*

58% Inhibition in our initial single dose assay, not evaluated in the dose response assay.