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. Author manuscript; available in PMC: 2012 Jan 11.
Published in final edited form as: Tuberculosis (Edinb). 2009 Sep 15;89(5):334–353. doi: 10.1016/j.tube.2009.05.008

Table 4.

Antitubercular Activity of Certain Benzopyran-2-one-3-carboxamides

graphic file with name nihms-146470-t0010.jpg
Cpd.No. R1 R2 R3 TB
IC90 		SI
3a CO2Et H Et 0.89 >17
3b CO2i-Pr H Me 1.4 >11
3c CONH2 -(CH2)6- 2.9 >5.2
3d CO2Me -(CH2)3- 7.7 >1.9
3c CO2Et H 2-thienyl 9.1 >1.7
3f CO2Me H n-Pr 50 -
3g CO2Et Ph Me Inact. -
3h CO2Et 4-(CH3)Ph H * -
*

87% Inhibition in our initial single dose assay, not evaluated in the dose response assay.