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. Author manuscript; available in PMC: 2012 Jan 11.
Published in final edited form as: Tuberculosis (Edinb). 2009 Sep 15;89(5):334–353. doi: 10.1016/j.tube.2009.05.008

Table 7.

Representative Antitubercular Activities of Phenoxyalkylimidazoles

graphic file with name nihms-146470-t0016.jpg
Cpd. No. R1 R2 R3 R4 R5 n TB
IC90 		SI
6a Cl H Br H H 4 1.3 >8.3
6b Cl H Br H H 3 24 >0.6
6c Cl H Br H H 2 Inact. ---
6d H H s-Bu H H 4 1.4 >11
6e H H s-Bu H H 2 3.0 >5
6f H Cl Cl H H 4 2.5 5.9
6g H Cl Cl H H 3 4.9 >3.1
6h H Cl Cl H H 2 10 ---
6i t-Bu H Cl H H 4 2.2 >6.9
6j t- Bu H Cl H H 2 2. 8 >5.4
6k t- Bu H H H Me 2 11 >1.4
6l H Me i-Pr H H 4 2.9 >5.2
6m H Me i-Pr H H 3 5.9 >2.5
6n H Me H i-Pr H 4 2.6 >5.8
6o Me H H i-Pr H 4 2.5 >6.1
6p i-Pr H H Me H 4 3.1 >4.9
6q Br H Cl H H 4 1.7 >9.0
6r Cl H Cl H H 5 4.4 >3.4