Skip to main content
. Author manuscript; available in PMC: 2012 Jan 11.
Published in final edited form as: Tuberculosis (Edinb). 2009 Sep 15;89(5):334–353. doi: 10.1016/j.tube.2009.05.008

Table 8.

Antitubercular Activities of 8-Hydroxyquinolines

graphic file with name nihms-146470-t0017.jpg
Cpd.
No.		 R1 R2 R3 R4 TB
IC90 		SI
11a COMe H H trans-HC=CHPh(3-Br) <0.10 >150
11b H H Br H <0.10 >150
11c COEt H H trans-HC=CHPh(2-F) 0.11 >135
11d COMe H H trans-HC=CHPh(4-Cl) 0.19 >79
11e H H H trans-HC=CHPh(3-F) 0.20 >75
11f H H H trans-HC=CHPh(4-OMe) 0.20 >75
11g COEt H H trans-HC=CHPh(3,4-OCH2O-) 0.29 >51
11h COPh(2-NO2) Cl Cl H 0.32 >47
11i COMe H H trans-HC=CHPh(4-F) 0.33 >45
11j CO-2-thiophene H Cl H 0.50 >30
11k H H H trans-HC=CHPh(3-OMe, 4-OH) 0.54 >28
11l COMe H H trans-HC=CHPh(2-Cl, 6-F) 0.94 >16