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. Author manuscript; available in PMC: 2012 Jan 11.
Published in final edited form as: Tuberculosis (Edinb). 2009 Sep 15;89(5):334–353. doi: 10.1016/j.tube.2009.05.008

Table 9.

Antitubercular Activities of 4-Aminoquinolines

graphic file with name nihms-146470-t0018.jpg
Cpd.No. R1 R2 R3 R4 R5 TB
IC90 		SI
12a 4-n-propoxyphenyl H Me H Cl 0.83 18
12b 4-benzyloxyphenyl H Me H COOMe 1.9 7.7
12c 4-N-piperidinylphenyl H Me H COOEt 3.0 5.0
12d 3,4-ethylenedioxyphenyl COOEt H H OMe 3.4 4.5
12e 4-ethoxyphenyl H Me H COOMe 5.6 2.7
12f 4-N,N-dimethylaminophenyl H Me Me H 6.2 2.4
12g 2-hydroxyphenyl H Me H OMe 10 ---