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. 2011 Oct 11;20(1):101–108. doi: 10.1038/mt.2011.212

Figure 3.

Figure 3

Intravitreous 21-nucleotide (nt)-short-interfering RNA (siRNA) administration suppresses retinal function. Representative wave form and amplitude responses during scotopic flash electroretinography (ERG) in mice are shown. Weekly intravitreous administration of 21-nt-Luc-siRNA for a total of three injections resulted in significant decrease of the a- and b-wave amplitude responses by 15.8 ± 0.87% and 13.2 ± 0.39%, respectively, compared to phosphate-buffered saline (PBS) control (n = 8 per group in two independent experiments, *P < 0.05, Mann–Whitney U test).