FIG 8.

The presence of C. albicans SC5314 during cefoperazone recovery results in gastric colonization and erosions of the limiting ridge. The stomach was removed at day 21 postantibiotic and differentially cultured to determine C. albicans SC5314 colonization in conventional untreated, antibiotic-treated (Cef), SC5314-colonized alone (SC5314), or Cef/SC5314 mice (A). Histological sections were stained with H&E to look for evidence of inflammation during cefoperazone-induced microbiota disruption (B). At day 7 postantibiotic, 17% of the SC5314 mice and 83% of the Cef/SC5314 mice had detectable C. albicans CHN1. At day 21 postantibiotic, 20% of the SC5314 mice and 67% of the Cef/SC5314 mice had detectable C. albicans SC5314 in the stomach. LOD, limit of detection (*, P < 0.05 versus untreated).