Fig 4.
Mice vaccinated by infection with Y. pseudotuberculosis mE are protected from lethal challenge by Y. pestis. Groups of C57BL/6 mice were immunized (I) by inoculation i.g. with 5 × 108 CFU of mE or left uninfected (UI). Four weeks later, mice were i.v. challenged with either 103 CFU or 105 CFU of Y. pestis KIM D27, and survival was monitored for 28 days. The number of mice in each treatment group is indicated in parentheses. The data shown are the summary of two independent experiments, with one experiment using the 103 CFU dose and the second using the 105 CFU dose.