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. 2012 Jan;80(1):369–380. doi: 10.1128/IAI.05470-11

Table 5.

Renal and intestinal lesion scores in Dutch Belted rabbits infected with CG or BBG EHEC O157 strainse

Group Lesion score (mean ± SEM)d
Renal glomerular
 Renal vascular
 Cecal
Capillary thickening Luminal constriction WBC infiltration RBC fragmentation Intimal swelling Perivascular edema Vasculopathy
Negative control (sham) 0.32 ± 0.12 0.68 ± 0.17 1.11 ± 0.20 0.46 ± 0.12 0.29 ± 0.10 0.43 ± 0.15 0.11 ± 0.06
Positive control (EDL933) 0.73 ± 0.17 0.73 ± 0.15 1.33 ± 0.14 0.77 ± 0.21 0.13 ± 0.06 0.30 ± 0.10 0.80 ± 0.19a*†
E5252 (CG-3) 1.0 ± 0.26a* 1.58 ± 0.15a**,b** 1.25 ± 0.11 1.42 ± 0.30a** 1.17 ± 0.21a**†,b***† 1.17 ± 0.21a*,b**† 1.17 ± 0.42a**†
E3046 (CG-3) 0.67 ± 0.36 1.0 ± 0.18 1.08 ± 0.24 0.92 ± 0.37 0.83 ± 0.21a*,b** 0.92 ± 0.15a*,b** 0.75 ± 0.25a**
E2325 (CG-1) 0.20 ± 0.12 0.80 ± 0.34 1.30 ± 0.37 0.20 ± 0.12 0.10 ± 0.10 0.20 ± 0.12 0.50 ± 0.16a*
E6996 (BBG-6) 0.42 ± 0.20 0.58 ± 0.15 1.58 ± 0.42 0.67 ± 0.21 0.08 ± 0.08 0.33 ± 0.11 0.67 ± 0.31a*
E5880 (BBG-5) 0.33 ± 0.17 0.83 ± 0.28 0.67 ± 0.21b* 1.17 ± 0.21a* 0.25 ± 0.11 0.58 ± 0.24 0.33 ± 0.17
All CG 0.65 ± 0.17 1.15 ± 0.15a,b,c 1.21 ± 0.14 0.88 ± 0.20 0.74 ± 0.15a*,b**†,c**† 0.79 ± 0.14b** 0.82 ± 0.18a***†
All BBG 0.38 ± 0.13 0.71 ± 0.16 1.13 ± 0.26 0.92 ± 0.16a* 0.17 ± 0.07 0.46 ± 0.13 0.50 ± 0.17a*
a

Sham-inoculated rabbits.

b

EDL933-inoculated rabbits.

c

CG relative to BBG.

d

Superscript letters indicate comparisons within each CG or BBG column relative to sham- and EDL933-inoculated rabbits and for CG relative to BBG. Asterisks indicate significance levels as follows: *, P ≤ 0.05; **, P < 0.01; ***, P < 0.001. Unless otherwise indicated, group differences were identified using the Mann-Whitney two-tailed test; “†” indicates use of the Kruskal-Wallis test with Dunn's multiple comparison test. Unless otherwise indicated, the statistical difference was identified by the Mann-Whitney two-tailed test.

e

Rabbits were euthanized on day 6 or 7 p.i. (sham), day 4, 6, or 7 p.i. (EDL933), day 4 or 7 p.i. (E5252 and E3046), day 6 p.i. (E2325), and day 7 p.i. (E6996 and E5880). Abbreviations: WBC, white blood cells; RBC, red blood cells.