Fig 5.
Factor XI-deficient mice display reduced hepatic pathology during listeriosis. (A and B) Lesions observed in hematoxylin-and-eosin-stained liver sections from FXI wild-type (A) and FXI KO (B) mice that had been inoculated with a high dose (∼2.5 × 106 CFU) of L. monocytogenes 3 days prior to tissue collection. (C) Histological scoring of inflammatory foci revealed significant differences in the numbers of type 3 foci per section (P = 0.009; n = 5 mice per group). The micrographs in panels A and B depict representative type 3 and 2 foci, respectively. See Materials and Methods for definitions of focus types.