Fig 2.

C. difficile infection following clindamycin treatment results in persistent intestinal inflammation. Mice were treated with clindamycin (200 μg) intraperitoneally on day −1 and infected with 10³ C. difficile spores on day 0. (A and B) Uninfected mice and mice infected 2, 4, 7, 10, and 30 days postinfection were sacrificed, and their ceca were isolated and fixed, and tissue sections were stained with hematoxylin and eosin. Cecum sections were scored for edema (thin arrows), inflammatory cell infiltration (white arrows), and epithelial cell loss (arrowheads). Scale bar, 200 μm (inset, 50 μm). *, P < 0.05 (Mann-Whitney test).