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Single-dose clindamycin treatment does not reduce 16S rRNA gene copy numbers in the ileum and cecum. The quantity of 16S rRNA gene copies was determined by qPCR of ileal (A, B, and C) and cecal (D, E, and F) samples from mice that received clindamycin (200 μg) intraperitoneally on day −1 and/or inoculation of 103 C. difficile spores on day 0. Samples were obtained on days (postinfection) indicated. Each bar represents the average of three mice.
