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. 2012 Jan;80(1):121–130. doi: 10.1128/IAI.05965-11

Table 1.

Conjunctival gene expression in relation to clinical phenotypea

Geneb TSI vs C
 TS vs C
 Inflamed vs noninflamed
FC P FC P FC P
S100A7 5.54 <0.0001 3.2 <0.0001 1.3 0.11
SAA1 4.99 <0.0001 2.11 <0.0001 1.6 0.04
DEFB4A 4.72 <0.0001 1.42 0.01 2.46 <0.0001
CXCL5 3.89 <0.0001 1.18 0.43 3.4 <0.0001
MMP12 3.55 <0.0001 1.74 <0.0001 1.62 0.0002
INDO 3.29 <0.0001 1.5 <0.0001 1.96 <0.0001
MMP9 3.06 <0.0001 1.76 <0.0001 1.67 <0.0001
IL1B 2.57 <0.0001 1.59 <0.0001 1.48 0.0003
NOS2 2.16 <0.0001 1.27 0.005 1.38 0.007
MMP7 2.14 <0.0001 1.23 0.003 1.51 <0.0001
CD83 1.9 <0.0001 1.4 <0.0001 1.31 0.0004
IL13RA2 1.62 0.006 1.38 0.008 1.08 0.65
IL12B 1.52 0.02 1.29 0.04 1.22 0.23
TNFA 1.47 <0.0001 1.14 0.008 1.23 0.003
IL-10 1.46 0.2 0.64 0.03 1.27 0.42
TIMP1 1.46 <0.0001 1.4 <0.0001 0.93 0.3
IFNG 1.42 0.001 1.06 0.4 1.41 0.002
ARG1 1.3 0.01 1.25 0.0003 1.04 0.64
IL-13 1.22 0.3 1.17 0.19 1.09 0.64
CFH 0.75 <0.0001 1.13 0.005 0.68 <0.0001
MMP1 0.58 0.009 1.28 0.05 0.63 0.02
MMP10 0.38 <0.0001 0.86 0.02 0.54 <0.0001
SPARCL1 0.06 <0.0001 0.51 <0.0001 0.19 <0.0001
a

TSI versus C and TS versus C values were adjusted for age and sex. Inflamed versus noninflamed values were adjusted for age, sex, and level of clinical scarring. Using a Bonferroni correction for 69 comparisons, a P value of <0.0007 would be considered significant. See the text for discussion. TSI, trachomatous scarring with inflammation; TS, trachomatous scarring without inflammation; FC, fold change.

b

S100A7 = S100 calcium binding protein A7; SAA1 = serum amyloid A1; DEFB4A = defensin, beta 4A; CXCL5 = chemokine (C-X-C motif) ligand 5; MMP12 = matrix metalloproteinase 12; INDO = indoleamine-2,3-dioxygenase; MMP9 = matrix metalloproteinase 9; IL1B = interleukin-1; NOS2 = nitric oxide synthase 2, inducible; MMP7 = matrix metalloproteinase 7; CD83 = CD83 molecule; IL13RA2 = interleukin 13 receptor, alpha 2; IL12B = interleukin-12β; TNFA = tumor necrosis factor, alpha/beta; IL-10 = interleukin 10; TIMP1 = TIMP (tissue inhibitor of matrix metalloproteinase) matrix metalloproteinase inhibitor 1; IFNG = interferon gamma; ARG1 = arginase, liver; IL-13 = interleukin-13; CFH = complement factor H; MMP1 = matrix metalloproteinase 1; MMP10 = matrix metalloproteinase 10; SPARCL1 = SPARC (secreted protein, acidic, cysteine-rich)-like 1 (hevin).