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. 2012 Jan;32(1):126–138. doi: 10.1128/MCB.06077-11

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Fig 7 — SMN deficiency exacerbates Cdkn1a mRNA upregulation in SMA motor neurons. RT-qPCR analysis of Cdkn1a mRNA expression in whole spinal cord (A) as well as motor neurons (LCM MN) and non-motor neurons (LCM non-MN) (B) isolated from control (Smn^+/−; SMN2^+/+; SMNΔ7^+/+; GFP^+/−) and Δ7 SMA (Smn^−/−; SMN2^+/+; SMNΔ7^+/+; GFP^+/−) mice at postnatal day 6. Data were normalized to GAPDH, and for each group, Cdkn1a mRNA levels in Δ7 SMA were expressed relative to those in control. Values represent means and SEM from independent experiments (n=8; *, P < 0.05; ***, P < 0.001).