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. Author manuscript; available in PMC: 2012 Nov 23.
Published in final edited form as: Cell. 2011 Nov 23;147(5):1011–1023. doi: 10.1016/j.cell.2011.09.055

Figure 7. Gi-Gq Balance Model of the Mechanism of Action of Antipsychotic and Psychedelic Drugs through the mGluR2/2AR Complex.

Figure 7

Formation of the receptor complex establishes an optimal Gi-Gq balance in response to Glu and 5-HT (increase in Gi, decrease in Gq). A. Psychedelics (LY34 and DOI) invert the balance (strong Gi decrease, strong Gq increase). B. Disruption of the optimal balance in psychotic states (decrease in Gi, increase in Gq) can be compensated for by antipsychotics (LY37, clozapine, and risperidone) that recover the Gi-Gq balance (increasing Gi and decreasing Gq).