Fig 3.

Homotypic blockade of GII.4-2002 VLP-B trimer interaction by anti-GII.4-2002 MAbs. (A) GII.4-2002 VLPs were incubated with increasing concentrations of anti-GII.4-2002 MAbs, and the mean percent control binding was calculated by comparing the amount of VLP bound in the presence of antibody pretreatment to the amount of VLP bound in the absence of antibody pretreatment. Error bars represent the standard errors of the means. (B) Mean MAb concentration (μg/ml) needed to block 50% of GII.4-2002 ligand binding. The mean titer is indicated by the line in the graph. The upper and lower broken lines in the graph represent the maximum and minimum values. The asterisk indicates an antibody with a BT50 significantly different from that of GII.4-2002-G1.