Table 3.
Summary of ELISpot responses to Gag peptides identified by iTopia epitope discovery system screening
| Peptide |
Patient sample |
Mean SFU/million | ||
|---|---|---|---|---|
| Allele | Sequence | Tested | Responded | |
| A*01:01 | NSSKVSQNY | 12 | 3 | 79 |
| TTEGCQQIM | 7 | 3 | 77 | |
| YVDRFFKTL | 7 | 2 | 2,148 | |
| SSSKVSQNY | 5 | 2 | 115 | |
| NSSQVSQNY | 5 | 4 | 96 | |
| HSNQVSQNY | 5 | 4 | 115 | |
| HSSQVSQNY | 5 | 4 | 74 | |
| NSSQVSRNY | 5 | 3 | 127 | |
| SSSQVSQNY | 5 | 4 | 130 | |
| B*07:02 | APPAEIFGM | 8 | 1 | 100 |
| APRKKGCWK | 8 | 2 | 148 | |
| FPQSRPEPT | 7 | 1 | 55 | |
| GPGATLEEM | 5 | 1 | 80 | |
| GPGHKARVL | 8 | 2 | 83 | |
| GPIPPGQMR | 5 | 1 | 215 | |
| GPSHKARVL | 8 | 3 | 62 | |
| RALGPGATL | 5 | 3 | 115 | |
| RLRPGGKKK | 5 | 1 | 135 | |
| RPGNFPQSR | 5 | 1 | 80 | |
| SPRTLNAWV | 8 | 2 | 245 | |
| TPQDLNMML | 5 | 1 | 905 | |
| TPQEQIGWM | 5 | 1 | 185 | |
| TPQEQLGWM | 4 | 0 | <50 | |
| VRMYSPVSI | 4 | 1 | 435 | |
| WPSSKGRPG | 8 | 3 | 115 | |
| YPLVSLKSL | 8 | 2 | 703 | |
| YVDRFFKTL | 8 | 2 | 1,280 | |
| GPGHKARVL | 8 | 4 | 84 | |
| GPSHKARVL | 8 | 6 | 95 | |
| KARVLAEAM | 8 | 5 | 78 | |
| QVQHTNIMM | 8 | 6 | 87 | |
| QAQQPNVMM | 8 | 5 | 96 | |
| QVNGNTAIM | 8 | 6 | 99 | |
| QANANTAIM | 8 | 6 | 109 | |
| ATNANAAIM | 8 | 5 | 95 | |
| NIMMQRGNF | 8 | 3 | 100 | |
| NIMMQRSNF | 8 | 6 | 121 | |
| NVMMQRSNF | 8 | 6 | 117 | |
| AIMMQRGNF | 8 | 4 | 113 | |