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. 2012 Jan;86(2):1214–1226. doi: 10.1128/JVI.06189-11

Fig 11.

Fig 11

Homology models comparing GII.4-1987, GII.4-2006, and GII.4-1987(+06D). (A) Overlay of binding pocket of GII.4-1987 (yellow), GII.4-2006 (purple), and GII.4-1987(+06D) (gray). Side chains are shown for residues in sites 1 and 2 (residues 342 to 347, 374, 390 to 395, and 440 to 444). Residues 393 to 395 are shown in teal [GII.4-1987(+06D)], orange (GII.4-1987), and red (GII.4-2006). (B) Residue 390 (yellow) forms a hydrogen bond with residue 395 (yellow) in GII.4-1987(+06D) that is not found in GII.4-2006. GII.4-2006 residues 393 and 395 form hydrogen bonds not found in GII.4-1987(+06D). (C) Residue 343 (yellow) forms a hydrogen bond (red arrow) with the FUC of HBGA B (orange) in GII.4-1987(+06D) but not with that of GII.4-2006. (D) Three hydrogen bonds are formed between residue 345 (yellow) and the FUC of HBGA B in GII.4-2006, but only one is formed with GII.4-1987(+06D). (E) Residues 343 and 444 (both yellow) share a hydrogen bond in GII.4-1987(+06D) but not in GII.4-2006. (F) Residue 442 (yellow) participates in hydrogen bonding with the FUC of HBGA B in GII.4-1987(+06D) but not with that of GII.4-2006. In GII.4-1987(+06D), residue 442 (yellow) also forms a hydrogen bond with residue 443, which is not found in GII.4-2006.