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Epitope A chimeric VLP reactivity with synthetic HBGAs. Synthetic CHOs were diluted to 10 μg/ml and assayed by the CHO binding assay for interaction with GII.4-1987, GII.4-2006, and GII.4-2006(+87A.1). Amino acid residues from GII.4-1987 were inserted into the GII.4-2006 backbone at positions 294, 297 to 298, 368, and 372. The dashed line represents 3 times the background level of binding and indicates a positive signal.
