Table 1.
Relatedness of sooty mangabey and human 7TMRs
| SM 7TMR | % Overall amino acid identity to 7TMR froma: |
No. of residues differing from human receptorb: |
||
|---|---|---|---|---|
| Human | Rhesus macaque | NTD | ECL2 | |
| APJ | 98.7 | 99.7 | 0 | 1 |
| CCR2b | 96.7 | 99.2 | 1 | 2 |
| CCR3 | 91.3 | 98.6 | 6 | 4 |
| CCR4 | 98.6 | 100.0 | 0 | 1 |
| CCR8 | 94.4 | 99.2 | 8 | 1 |
| CXCR4 | 98.3 | 99.4 | 3 | 2 |
| CXCR6 | 94.5 | 98.3 | 8 | 2 |
| GPR1 | 97.7 | 99.7 | 1 | 1 |
| GPR15 | 97.2 | 99.4 | 1 | 1 |
a
Alignment between predicted amino acid sequences of SM molecules cloned here and homologous human and rhesus macaque sequences from GenBank.
b
Number of predicted amino acids differences between SM and human molecules in the N-terminal domain (NTD) and extracellular loop 2 (ECL2), two regions most relevant to coreceptor function based on mapping studies with CCR5 and CXCR4 (19).