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. 2012 Jan;86(2):991–1000. doi: 10.1128/JVI.05603-11

Fig 2.

Fig 2

Impact of selected mutations in the LLRHHNMVY2450-2458 and SQRQKKVTF2466-2474 epitopes on recognition by CD8+ T cells. (A) Specific CD8+ T cells were expanded from PBMCs of patient IDU229 in the presence of the prototype peptide LLRHHNMVY and then restimulated after 10 days with the variant peptides indicated in the figure, followed by ICS for IFN-γ. (B) Specific CD8+ T cells were expanded from PBMCs of patient IDU229 in the presence of the variant peptide LLRHHNLVY and then restimulated after 10 days with the peptides indicated in the figure, followed by ICS for IFN-γ. (C) Specific CD8+ T cells were expanded from PBMCs of patient IDU193 in the presence of the prototype peptide SQRQKKVTF and then restimulated after 10 days with the peptides indicated in the figure, followed by ICS for IFN-γ. In all experiments, irrelevant peptides served as a negative control.